Chapter Twenty-Two: Introduction to Disorders of Osmolality

June 29, 2026 2:21pm 1:09

ReferencesThis is the famous Edelman equation from JCI in 1958 by Isodore Edelman! Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total...

Chapter Twenty: Respiratory Acidosis

June 02, 2026 11:03pm 1:44

ReferencesBiff Palmer! Respiratory Acidosis and Respiratory Alkalosis: Core Curriculum 2023Josh what is sensed- pCO2 or pH and some exploration suggests that it is not settled! Sensing, physiological effects and molecula...

Chapter Twenty One: Respiratory Alkalosis

March 23, 2026 11:15pm 1:06

ReferencesChapter 19, Part 3 August 30, 2023Biff Palmer’s Ted Talk-Why not? Biff Palmer at TEDxSMU 2013Anna mentioned this issue of lactic acidosis in a panic disorder: The Lactic Acid Response to Alkalosis in Panic Diso...

Chapter 19

February 22, 2026 9:51am 1:57

ReferencesChapter 19, Part 3 August 30, 2023Joel and Roger mentioned the most common cause seems to be Sjögren’s syndrome for an acquired distal RTA. We mentioned this in an earlier episode and referenced this example of...

Chapter 19

October 11, 2025 1:40pm 1:45

ReferencesChapter 19, Part 12Metabolic acidosis  June 14, 2023ReferencesChapter 19, Part 2Roger mentioned MELAS syndrome MELAS syndrome: Clinical manifestations, pathogenesis, and treatment optionsJosh mentioned this blo...

Chapter 18

July 21, 2025 11:26pm 1:39

ReferencesPart 2, March 1, 2023The alkaline tide phenomenon in studies that measured both the alkaline tide and acid secretion, the bicarbonate accumulation increased in linear fashion with the acid secretion. Melanie th...

Chapter 19

June 01, 2025 10:39pm 1:45

ReferencesChapter 19, Part 1 Metabolic acidosis  June 14, 2023American Society of Nephrology | Medical Students - Kidney TREKS this is the program that Josh mentioned at Mount Desert Island! Effects of pH on Potassium: N...

Chapter 18

March 23, 2025 11:46am 1:05

We are a bit slappy at the beginning of the episode since we had just recorded our conversation with the Glaucomfleckens. ReferencesChapter 18 Metabolic alkalosis! Part 1 February 23, 2023It is chloride depletion alkalos...

Chapter 17

February 21, 2025 9:20am 1:31

ReferencesI said I used MDCalc but I was mistaken I use MedCalX which is nice but getting dated. We talked about this out of print book that we love: Cohen, J. J., Kassirer, J. P. (1982). Acid-base. United States: Little...

Chapter 16 part 2

January 28, 2025 9:27pm 1:27

ReferencesWe talked about winning the 2022 ASN innovation contest and here’s a link to our promo video https://www.dropbox.com/scl/fi/g4osnf0nradsfryyo51fi/ASN-Education-Contest-Channel-Your-Enthusiasm-Podcast.mp4?rlkey=...

Outline Chapter 16 — Edematous States Edema is a palpable swelling produced by expansion of the interstitial fluid volume Conditions associated with this Heart failure Cirrhosis Nephrotic syndrome Pathophysiology of edema formation Two steps Alteration of capillary hemodynamics that fav

December 19, 2024 6:49pm 1:18

ReferencesCapillary Hemodynamics  Insights into Salt Handling and Blood Pressure | NEJMAmy mentioned about the 3 phases of the interstitiumAre the precapillary sphincters and metarterioles universal components of the mic...

Chapter 15 part 2 — Clinical Use of Diuretics

August 16, 2024 11:42pm 1:36

ReferencesProximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice Melanie is in love with this paper that shows that sodium retenti...

Chapter 15 — Clinical Use of Diuretics

May 13, 2024 6:18pm 2:00

Outline Chapter 15 — Clinical Use of Diuretics- Among most commonly used drugs- Block NaCl reabsorption at different sites along the nephron- The ability to induce negative balance has made them useful in multiple diseas...

Chapter fourteen: The Hypovolemic State, part 2

March 24, 2024 12:14pm 1:39

Outline Chapter 14 — Treatment- Treatment - Both oral and IV treatment can be used for volume replacement - The goal of therapy are to restore normovolemia - And to correct associated acid-base a...

Chapter fourteen: The Hypovolemic State, part 1

January 28, 2024 9:44pm 1:45

OutlineChapter 14- Hypovolemic States- Etiology - True volume depletion occurs when fluid is lost from from the extracellular fluid at a rate exceeding intake - Can come the GI tract - Lungs - Uri...

Chapter Thirteen: The Meaning and Application of Urine Chemistries

September 17, 2023 10:29pm 1:31

ReferencesJC mentioned that the diagnostic accuracy of 24 hour urine collection increases with more collections! Metabolic evaluation of patients with recurrent idiopathic calcium nephrolithiasisWe didn't refer to a part...

Chapter Eleven: Regulation of Acid-Base Balance, part 2

May 20, 2023 2:01pm 1:30

ReferencesWe considered the complexity of the machinery to excrete ammonium in the context of research on dietary protein and how high protein intake may increase glomerular pressure and contribute to progressive renal d...

NKF 2023 Diuretic Draft

April 14, 2023 3:31pm 1:51

The Channelers went where no nephrology podcasters have gone before, recording in front of a live audience at the National Kidney Foundation Clinical Meeting in Austin. We had all eight Channelers doing a live podcast.We...

A Very Special Episode: Meet the Glaucomfleckens

March 04, 2023 1:07pm 56 min

Chapter Eleven: Regulation of Acid-Base Balance, part 1

February 12, 2023 5:01pm 1:37

ReferencesWe considered the effect of a high protein diet and potential metabolic acidosis on kidney function. This review is of interest by Donald Wesson, a champion for addressing this issue and limiting animal protein...